GAMMA GLOBULIN AND COMPLEMENT IN THE DISEASED KIDNEY

Gamma globulin and complement in the diseased kidney.

Complement Fixation in Diseased Tissues

An immunohistologic complement fixation test has been used in an effort to detect immune complexes in sections of kidney from rats injected with rabbit anti-rat kidney serum and in sections of biopsied kidneys from four humans with membranous glomerulonephritis. Sections of the rat and human kidneys were treated with fluorescein-conjugated anti-rabbit globulin or antihuman globulin respectively...

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog.

Increased catabolism of plasma proteins by leakage into the gastrointestinal tract and subsequent digestion by the intestinal enzymes are frequently the causes of hypoproteinemia (1-5). The presence of plasma proteins has been demonstrated both in saliva and in the gastric and intestinal juice of normal individuals; therefore, gastrointestinal leakage of plasma proteins may account for a substa...

The Cytotoxic Action of Immune Gamma Globulin and Complement on Krebs Ascites Tumor Cells

Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxi...

Phenotype and Gamma Globulin Levels

In 1964, de Grouchy described the clinical picture associated with partial monosomy for No. 18 chromosome due to a deletion of part of the long arms (de Grouchy et al., 1964a, b). Subsequent case reports have confirmed a phenotypic similarity in individuals with this deletion. Edwards and associates (1960) described a new autosomal trisomy, that of chromosome 18. Since their report, there have ...